| Title | [A comparative study of atenolol (Tenormin) and the combined preparation atenolol/chlorthalidone (Tenoretic Mite) in essential hypertension. A randomized double-blind study from general practice] |
| Author(s) | Pilgaard S, Palmelund VO, Svendsen TL |
| Institution | Centralsygehuset i Naestved, medicinsk afdeling. |
| Source | Ugeskr Laeger 1990 Apr 9; 152(15):1083-6. |
| MeSH | Adolescent
Adult
Aged
Atenolol
Chlorthalidone
Comparative Study
Double-Blind Method
Drug Combinations
Drug Evaluation
English Abstract
Female
Humans
Hypertension
Male
Middle Aged
Randomized Controlled Trials
|
| Abstract | Two hundred and ninety-two hypertensive patients from general practice who had previously been treated with a diuretic with insufficient effect participated in a randomised trial for a period of three months. A total of 115 patients completed treatment with 50 mg atenolol (Tanormin) and 121 were treated with the combined preparation consisting of 50 mg atenolol and 12.5 mg chlothalidone (Tenoretic Mite) while 56 patients defected from the trial. In both of the groups, the average blood pressure was reduced significantly already after treatment for one month. A significantly greater number of patients receiving combined treatment achieved satisfactory diastolic blood pressures (less than 90 mmHg), the proportions being 78% and 54%, respectively. Better effects from combined treatment were found particularly in patients over 60 years of age and in females. No significant differences were observed between the side-effects of the regimes nor in the laboratory values registered during treatment. |
| Language | dan |
| Pub Type(s) | Clinical Trial
Journal Article
Randomized Controlled Trial
|
| PubMed ID | 2184556 |
